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WAY 208466 dihydrochloride The aim of this study is
2022-03-03
The aim of this study is to explore new Glo-I inhibitors using the structure-based pharmacophore approach. Eighteen Glo-I co-crystallized structures have been explored to investigate their pharmacophoric features. Ninety two pharmacophoric models were generated. QSAR analysis followed by Ligand Prof
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A number of experimental data declare a tight interdependenc
2022-03-03
A number of experimental data declare a tight interdependence between the pathological changes of glutamate transport in TUG 891 and consequent alterations in glutamate transport and activity/expression of glutamate metabolizing enzymes in platelets (Aliprandi et al., 2005, Behari and Shrivastava,
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br WM astrocytes Grey matter astrocytes express a variety of
2022-03-03
WM astrocytes Grey matter astrocytes express a variety of GluR types that have both physiological and pathophysiological significance [87]. Non-NMDA GluR are also expressed in WM astrocytes [40], although the functionality of these receptors has not been tested. The fibrous astrocytes that popula
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Moreover to evaluate the properties of immobilized glucosida
2022-03-03
Moreover, to evaluate the properties of immobilized β-glucosidase further, the anti-protease test was also carried out. The result showed that the residual activity of the β-glucosidase@ZIF-8 was higher than that of the nano-SiO2@β-glucosidase and free β-glucosidase. Because free β-glucosidase and t
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GK also called hexokinase IV or D is a
2022-03-03
GK, also called hexokinase IV or D, is a glycolytic enzyme that converts SU6656 to glucose-6-phosphate. GK has unique characteristics compared with those of the ubiquitously expressed hexokinase isoforms I–III, and is predominantly expressed in the pancreas and liver. In pancreatic β-cells, GK regu
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br Experimental br Acknowledgments This project was generous
2022-03-03
Experimental Acknowledgments This project was generously supported by Grünenthal GmbH and IECB. We also thank the staff members of the technical platform of IECB and Grünenthal GmbH for their availability and their skills. Introduction Glucocorticoids (GCs) are essential steroid hormones t
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Whether histamine receptor distribution is altered in
2022-03-02
Whether histamine receptor distribution is altered in canine GI diseases remains unknown, but human research has documented altered histamine receptor density in certain GI diseases (Sander et al., 2006, Deiteren et al., 2015, Von Rahden et al., 2011). Additionally, a novel H4 receptor antagonist, J
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The more important effect of pitolisant
2022-03-02
The more important effect of pitolisant is related to its wake-promoting and arousal activities as a result of enhanced cmk release in animal models (Ligneau, Perrin, et al., 2007). Moreover, its potential in the treatment of severe excessive daytime sleepiness (EDS) in narcoleptic teenagers refrac
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br Materials and methods br Results Estimations of OMP gener
2022-03-02
Materials and methods Results Estimations of OMP generated by the proposed mechanism (Fig. 1) were first performed for the range of 0.001–2 mM of T0070907 concentration in the cytosol. It was assumed that only 5% of all VDACs in MOM form the ANT-VDAC1-HKI contact sites, and that the fraction
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The identity of organelles is defined by a
2022-03-01
The identity of organelles is defined by a particular set of molecules present on their surface. Most organelles in the endomembrane system (i.e., endoplasmic reticulum, Golgi apparatus, endosomes, and lysosomes) carry Rab GTPases (hereafter referred to as Rabs), which serve as binding platforms for
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(-)-epicatechin Based on the results of compound appeared
2022-03-01
Based on the results of , (-)-epicatechin appeared to have the best overall profile, so our efforts were then devoted to using 5-(-propyl)pyrimidine as the right-hand nitrogen attachment to optimize the R group of (). Analog was synthesized using the reaction conditions from , while analogs and were
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br Glucose metabolism and diet
2022-02-28
Glucose metabolism and diet Glucokinase is essential for sensing blood glucose levels, thus controls metabolism (Iynedjian, 1993, Iynedjian, 2009, Postic et al., 2001, Agius, 2008). Loss of glucokinase activity in humans and mice leads to diabetes (Printz et al., 1993b, Postic et al., 2001, Agius
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br Genetic manipulation variation of the
2022-02-28
Genetic manipulation/variation of the ghrelin system and alcohol-related outcomes Genetic manipulation of the ghrelin system (either the peptide or the receptor gene) via knockout rodent models has provided further insight into the role of this system in alcohol seeking and consummatory behaviors
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br Structures of human secretase Before the near
2022-02-28
Structures of human γ-secretase Before the near-atomic resolution structures, the highest resolutions achieved for γ-secretase were 15 and 12Å [19, 21]. The 15-Å structure revealed a SKF 81297 hydrobromide sale chamber in the transmembrane domain and two pores at the top and bottom of γ-secretas
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NBI 27914 hydrochloride receptor When we compared the effect
2022-02-28
When we compared the effects in FST induced by GAL and GAL(1–15), we observed that the increase in the immobility induced by GAL(1–15) was significantly higher than the one induced by GAL (Millon et al., 2015). Moreover, in climbing behaviour, GAL(1–15) also induced a stronger decrease in climbing r
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