• The binding of collagen X to DDR differs

  2020-08-04

  

  The binding of collagen X to DDR2 differs from the binding of collagen X to α2β1 integrin in that the triple helical conformation is essential for DDR2 binding. We previously reported that heat denatured pepsinised collagen X supported cell adhesion via α2β1, indicating that the triple-helical confo

• oxoG is the most common oxidative DNA lesion that

  2020-08-04

  

  8oxoG is the most common oxidative DNA lesion that has been studied in both eukaryotic and bacterial transcription systems. When located in the template DNA strand, it promotes misincorporation of Mesoridazine receptor and causes weak transcriptional pausing by both bacterial and eukaryotic RNAPs [

• cycloserine DGK is abundantly expressed in skeletal muscle w

  2020-08-04

  

  DGKδ is abundantly expressed in skeletal muscle [18], which is a major insulin-target organ for glucose disposal [19]. Chibalin et al. have demonstrated that a decrease in DGKδ expression increases the severity of type 2 diabetes [20]. Moreover, acute high glucose exposure increases DGKδ activity in

• The irreversible binding of the alkyl group to MGMT

  2020-08-03

  

  The irreversible binding of the alkyl group to MGMT protein functionally inhibits its enzyme activity and leads to protein degradation [8]. Proteasomal and lysosomal degradation are the two major processes for cellular protein turnover [9]. Protein ubiquitination is a chemical process in which ubiqu

• It has been reported by immunohistochemistry that chronic hy

  2020-08-03

  

  It has been reported by immunohistochemistry that chronic hypoxia enhances the immunoreactivity for TH in the CB (Wang et al., 1998, Wang and Bisgard, 2002, Hui et al., 2003). Although it is suggested that the CB of SHR/Izm is rendered regional hypoxia as mentioned earlier, immunoreactivity for TH i

• Researches aforementioned provide effective numerical theore

  2020-08-03

  

  Researches aforementioned provide effective numerical/theoretical descriptions of expansion behavior of PELE when small-caliber projectiles penetrating thin target at high impact velocity. Here we presented a similar study on large-caliber PELE projectile (130 mm) with various thickness steel jacket

• Over the past decade targeting DNA repair

  2020-08-03

  

  Over the past decade, targeting DNA repair proteins has emerged as an effective tool to enhance chemosensitivity of malignant cells [9]. However, identification and selection of the proper target of DNA repair pathways is critical to increase cytotoxic activity of chemotherapeutic agents in cancer c

• br Introduction DNA damage repair is essential life processe

  2020-08-03

  

  Introduction DNA damage repair is essential life processes for maintaining the integrity and stability of genomic DNA, in which many enzymes, bio-molecules and ribozymes participate (Friedberg, 2003, Sancar et al., 2004, McCabe et al., 2006). In particular, the ligation reaction of 5′-phosphate a

• While linear sequences are important they must be viewed

  2020-08-03

  

  While linear sequences are important, they must be viewed with some caution. One noteworthy example is the C1 domains which have attracted some interest as they are known to bind phorbol esters and DAG (reviewed in (Das and Rahman, 2014)). In this, it was not unreasonable to suspect that one or more

• br Significance Our studies describe the first functional pr

  2020-08-03

  

  Significance Our studies describe the first functional proteomic map of ligand binding regions that mediate substrate (ATP) and inhibitor binding in the poorly annotated active site of the mammalian diacylglycerol kinase (DGK) superfamily. Given the dearth of lipid kinase inhibitors available in

• The number substrate specificity and Ca dependence of

  2020-08-03

  

  The number, substrate specificity, and Ca2+ dependence of alternative NAD(P)H dehydrogenases vary significantly when different organisms are compared. For instance, Arabidopsis mitochondria may possess up to seven proteins, including three external dehydrogenases: two are NADH dehydrogenases, one of

• In our analysis polymorphisms in PTPN INS and

  2020-07-31

  

  In our analysis, polymorphisms in PTPN22, INS and IFIH1 showed an effect on the appearance of autoantibodies. For the INS SNP rs689 this finding is in line with earlier observations in the DIPP follow-up cohort [21], [22], in the observational cohort from Germany [20] and the international TEDDY coh

• DL-AP5 Sodium salt None of the inhibitors gave a complete bl

  2020-07-31

  

  None of the inhibitors gave a complete blockage of RvE1-stimulated [Ca2+]i. RvE1 works through several different signaling pathways. Here, we studied three possible pathways that RvE1 could activate and found that all three were used by RvE1. Although one pathway may be inhibited, [Ca2+]i can still

• Enolase EC has been known as

  2020-07-30

  

  Enolase (EC 4.2.1.11) has been known as a key enzyme in glucose metabolism, which is involved in the reversible dehydration of 2-phospho-d-glycerate (2-PGA) to phosphoenolpyruvate (PEP) in the glycolytic and gluconeogenesis pathways (Pal-Bhowmick et al., 2004; Rodriguez et al., 2006). Extensive stud

• br STAR Methods br Acknowledgments We would like

  2020-07-30

  

  STAR★Methods Acknowledgments We would like to thank the DNA cloning, Protein Production, DNA sequencing facility, and mass spectrometry teams of the MRC Protein Phosphorylation and Ubiquitylation Unit for their support. We would like to thank Prof. Dario Alessi, Prof. Ronald Hay, Prof. Philip

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