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HT modulates cortical and hippocampal pyramidal cell
2023-07-19
5-HT modulates cortical and hippocampal pyramidal cell function in a very complex manner, since most 5-HT receptor subtypes (excitatory as well as inhibitory) are expressed on pyramidal Nitecapone as well as GABAergic interneurons that exert inhibitory control over pyramidal cells (Leiser et al., 20
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In summary the role of HT and
2023-07-19
In summary, the role of 5-HT and different types of 5-HTRs in gating plasticity induction in neocortical circuits remains unclear, with variable and seemingly contradictory effects reported for LTP induction in cortical sensory fields (e.g., V1, enhanced LTP: Inaba et al., 2009, Kojic et al., 1997,
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Adenosine is an endogenous nucleoside that
2023-07-19
Adenosine is an endogenous nucleoside that plays pivotal roles in different physiological and pathophysiological processes by triggering specific cell-surface receptors both in the guanidine hydrochloride synthesis and in the periphery. The adenosine receptors (ARs) are four different subtypes of G
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To date the modes of actions of pharmaceuticals in humans
2023-07-19
To date, the modes of actions of pharmaceuticals in humans and mammals are well-known (Fent et al., 2006), whereas knowledge of aquatic organisms, particularly invertebrates, is limited. This is problematic as these contaminants/pollutants have potentially harmful effects on wildlife organisms that
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IAA-94 synthesis On the contrary evidence also
2023-07-19
On the contrary, evidence also suggests that autophagy plays a striking protective role in cancer cells. Highly burgeoning cancer IAA-94 synthesis require cellular building blocks for their metabolism and energy production. At this stage of cancer development, autophagy acts as a friend providing al
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Aurora A and B are required for the
2023-07-19
Aurora A and B are required for the control of mitosis whereas Aurora C is mainly invoved in meiosis (Goldenson and Crispino, 2015). Interestingly, Aurora B is partnered with inner centromere protein (INCENP), survivin and Borealin to form a chromosomal passenger complex (CPC) that is critical for t
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In contrast to TPX members of
2023-07-19
In Adenosine Kinase Inhibitor hydrate to TPX2, members of the CPC (Figure 1B), such as survivin, borealin, and INCEN-P, which associate with Aurora B/C in animals, do not appear to have obvious homologs in plants. Recently, however, a putative INCEN-P homolog, termed WYRD, has been identified [34].
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br Materials and methods br Results and
2023-07-19
Materials and methods Results and discussion In our previous studies (Matarneh et al., 2017), mitochondria were mechanically disrupted and separated into supernatant and pellet fractions by centrifugation. The causative agent for enhnced glycolytic flux was shown to be a protein that resides i
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Comparison of the GLUT positive plus ACLY
2023-07-19
Comparison of the GLUT1-positive plus ACLY negative group with the GLUT1-negative plus ACLY positive group indicated no significant difference with respect to disease-free survival and overall survival. However, some obvious differences in histological types were found in their formation. A previous
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In this paper we described synthesis biological evaluation a
2023-07-19
In this paper, we described synthesis, biological evaluation and docking study of 3-aroyl-1-(4-sulfamoylphenyl)thiourea derivatives 4a–o as 15-lipoxygenase inhibitors. Results and discussion Conclusion We designed and synthesized a novel of thiourea derivatives containing phenylsulfonamide mo
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Fig summarizes the oxidative metabolism of arachidonic acid
2023-07-19
Fig. 1 summarizes the oxidative metabolism of arachidonic BI-D1870 by lipoxygenases cyclooxygenases and cytochrome P450. Lipoxygenases in humans are expressed in a tissue-specific fashion: 5-LOX is mainly expressed in leukocytes, 12-LOX in platelets, and 15-LOX-1 in reticulocytes, eosinophils, and
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The LOX hydroxide metabolites are converted to secondary lip
2023-07-19
The 15-LOX hydroxide metabolites are converted to secondary lipid mediators such as lipoxin A4 from 15-HETE and protectin D1/resolvin D1 from 17-HDoHE [45] (Fig. S3). Importantly, all of these secondary lipid mediators have anti-inflammatory and pro-resolving properties [46], [47], [48]. Lipoxin A4
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br Aromatase inhibitors The aromatase enzyme P arom belongs
2023-07-19
Aromatase inhibitors The aromatase enzyme, P450arom, belongs to the super-family of P450 proteins which includes more than 480 members divided in 74 different families. P450arom is a unique member of family 19 [39], and is located in the endoplasmic reticulum of mammalian Zileuton that express th
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In recent years the higher lipophilicity
2023-07-19
In recent years, the ‘higher lipophilicity’-thus-‘better performance’ tenet, derived from the polar paradox theory applied to micro-structured media, was challenged by novel and unexpected experimental results. In particular, the synthesis of many complete series of fatty Fructose Colorimetric/Fluor
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Since the beginning of s more than papers about physiologica
2023-07-19
Since the beginning of 1990s, more than 17,000 papers about physiological relevance of antioxidants have been published according to data from web of science. Based on the available literature, it seems that assessing the antioxidant potential of food by means of in vitro assays or solely epidemiolo
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