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Over the last years numerous studies gave insights into sGC
2022-03-10
Over the last 15 years, numerous studies gave insights into sGC activation and binding of activators: Photoaffinity labelling studies with cinaciguat suggested the N-terminus of the β1 subunit as target region for this new drug [17]. Schmidt et al. identified the amino acids tyrosine 135, serine 137
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GSTP catalyzed reduction of Prdx enhances its peroxidase
2022-03-10
GSTP1-1 catalyzed reduction of Prdx6 enhances its peroxidase activity. Using standard NADPH/GR/GSH-coupled assays we used cell lysates from the transiently transfected ABT-199 synthesis to measure the influence of GSTP1 allelic variation on peroxidase activity. Specificity for detection of Prdx6 act
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Third we performed correlation analysis between
2022-03-09
Third, we performed correlation analysis between the results obtained using DMR agonist assay in HT-29 and Tango assay in the engineered U2OS cells. First, we compared their relative efficacy, the maximal responses after normalized to the maximal responses of zaprinast obtained using both DMR and Ta
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br Materials and methods br Results and
2022-03-09
Materials and methods Results and discussion Conflict of interest Introduction In the presence of continuous and excessive levels of nutrients, adipocytes become hypertrophic and release several pro-inflammatory adipocytokines such as interleukin-6 (IL-6), monocyte chemoattractant protei
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There was a statistical significant correlation between CD e
2022-03-09
There was a statistical significant correlation between CD39 expression on CD4+ T cells and CD38 and ZAP-70 (Table 3). Del 6q was detected in 19 patients (63.3%) with a range of 2–75% and a mean of 32.97 ± 14.85. As regards to the staging system, del 6q was significantly higher in high risk group o
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Adenosine triphosphate ATP is thought to be a crucial molecu
2022-03-09
Adenosine triphosphate (ATP) is thought to be a crucial molecule in acute pain signaling in the DRG, as well as in the development and maintenance of chronic pain (Burnstock, 2009, Burnstock, 2013, Burnstock, 2014, Chizh and Illes, 2001). Extracellular ATP activates the ionotropic P2X receptors (Bur
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Koumine br Material and methods br Results br Discussion Neu
2022-03-09
Material and methods Results Discussion Neurosteroids capable of blocking the NMDAR channel attract a lot of attention as possible therapeutic agents for the treatment of neurodegenerative diseases. A large number of new Koumine with different structures have been synthesized in order to cr
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It is an aspiring task to apply the glutamate biosensor
2022-03-09
It is an aspiring task to apply the glutamate biosensor for in vivo measurements in hth 7 in 1 tissue. Due to a relatively large size of the electrode used in this work, the biosensor fits only ex vivo applications. However, it is possible to apply platinum microelectrodes 50–100 μm in diameter for
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A key limiting factor in the semi quantitative analysis
2022-03-09
A key limiting factor in the semi-quantitative analysis of changes in the nuclear-to-cytoplasmic distribution of glucokinase is the large intercellular heterogeneity of NCT-502 australia of glucokinase in both isolated hepatocytes in vitro and also in liver in vivo[13], [23], [24], [26], [36]. This
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In type diabetic subjects with mean
2022-03-09
In type-2 diabetic subjects with mean baseline glycated hemoglobin A (HbA) of 8.4%, q.d. administration of MK-0893 for 12weeks as a monotherapy resulted in dose-dependent decreases in HbA and FPG. Administration of MK-0893 q.d. at doses of 20, 40, 60, and 80mg led to observed reductions in HbA of 0.
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As cardiovascular disease accounts for the majority of
2022-03-09
As cardiovascular disease accounts for the majority of deaths in subjects with T2D, it is imperative that we better characterize the cardiovascular risks and benefits of the various therapies we prescribe to these individuals to control their glycemia. Indeed, the potential to identify subsets of di
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br Introduction For decades regulated apoptosis and unregula
2022-03-09
Introduction For decades, regulated apoptosis and unregulated, accidental necrosis have been considered as the two sole cell death routes in multicellular organisms. With the beginning of the 21st century a paradigm shift has been witnessed by researchers in the field with the recognition that ma
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Several other assay parameters were also explored First the
2022-03-09
Several other assay parameters were also explored. First, the thermal dependence of the assay was investigated by measuring the specific activity at different temperatures (Fig. 7). That data show that enzymatic activity increases with increasing temperature. Interestingly, the observed rate increas
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The cortical actin filaments are
2022-03-09
The cortical CID 755673 filaments are arranged in a network abuting the plasma membrane with a thickness of ∼190nm in living cells, that displays highly dynamic behaviors 15, 16, 17. Technical challenges, however, have hampered investigation of the detailed function dynamic interactions between the
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Over the last decade intense efforts have
2022-03-09
Over the last decade, intense efforts have been devoted toward identifying IN inhibitors as potential drugs against HIV. Raltegravir and elvitegravir are integrase strand transfer inhibitors (INSTIs) that have been approved for therapy and dolutegravir is another INSTI that is currently in advanced
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