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At baseline Hdc KO mice have
2021-11-10
At baseline, Hdc-KO mice have alterations in the examined signaling cascades that resemble those seen in WT mice after RAMH challenge. Specifically, Fmoc-Ser-OH of MSK1 at T581 and of rpS6 ad S235/236 are elevated in dMSNs to a similar extent after saline in KO mice and after RAMH challenge in WT s
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The glycolytic activator phosphofructo kinase fructose bisph
2021-11-10
The glycolytic activator 6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase 3 (PFKFB3) is well-known as a downstream substrate of hypoxia-inducible factor 1α (HIF-1α) signaling pathway [5,6]. Tumor hypoxia has long been associated with increased malignancy, poor prognosis and drug resistance. HIF-
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GSK2118436 br Conclusion The addition of cellulose to natura
2021-11-09
Conclusion The addition of GSK2118436 to natural substrate increases the number of H-bonds which indicates an increase in the stability of the docking systems. The investigated compounds are more stable than natural substrate in docking systems, where the natural substrate has two H-bonds while
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br Specificity of CD T
2021-11-09
Specificity of CD4 T cells and their role in flavivirus neutralizing antibody responses CD4 T cells recognize peptides that are proteolytically processed from protein antigens and presented by MHC class II molecules on the surface of specialized antigen-presenting cells, such as dendritic cells o
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In addition http www apexbt
2021-11-09
In addition to genomics, transcriptomics and proteomics tools, metabolomics approaches are now used in order to optimize glycoprotein production in CHO cell lines. Recent advances in metabolite quantification have allowed identification of cellular phenotypes under specific experimental conditions
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Functional studies based on patch clamp electrophysiology
2021-11-09
Functional studies based on patch-clamp electrophysiology provide additional information on the active state of GlyR α1. Current-voltage measurements from single ITD 1 in outside-out patches at symmetric 145-mM chloride concentration yielded a unitary conductance of 86 pS for the main open state an
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promotion Anderson et al reported a markedly decreased malad
2021-11-09
Anderson et al reported promotion markedly decreased maladaptive behavior traits of the VABS maladaptive behavior score after using EAA (Equine Assisted Activities) (F(1,11) = 5.65, = 5.65, (F(1,11) = 5.19, p = 0.04). However, the results of other EQ/SQ parts and of the VABS correlated with EAA did
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br Sodium glucose co transporter inhibitors SGLT
2021-11-09
Sodium-glucose co-transporter-2 inhibitors (SGLT2i) are the latest class of non-insulin glucose-lowering agents that facilitate glycaemic control by inhibiting renal glucose reabsorption, thus promoting glycosuria. Canagliflozin, dapagliflozin, and empagliflozin are the three commonly used agents
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br Conclusion and future directions GS is an important
2021-11-09
Conclusion and future directions GS is an important therapeutic target for the treatment of Alzheimer's disease. Its structure and function have been studied during the last years to understand the substrate cleavage mechanism to modulate the Aβ42 peptide production. The recent elucidation of GS
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pmsf br Introduction The mammalian skin
2021-11-09
Introduction The mammalian skin forms the largest organ of the body and includes a network of cutaneous nerves, cells of the immune system, and mediators of the neuro-endocrine axis (Theoharides et al., 2016). Analogous to the hypothalamic-pituitary-adrenal axis, neuropeptides and their receptors
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There are additional implications of subunit alterations
2021-11-09
There are additional implications of α2-subunit alterations in the hippocampus. P has anticonvulsant activity (Herzog, 1995, Herzog et al., 1997, Herzog et al., 2012, Reddy et al., 2001, Reddy, 2010). These actions result from the metabolic conversion of P to GABA-A receptor-modulating, antiseizure
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br Discussion and concluding remarks FPR is considered
2021-11-09
Discussion and concluding remarks FPR1 is considered to be a promising drug target for treating inflammatory and immunological diseases. Thus, natural compounds that could block and/or regulate FPR1 activity may be an important source of novel therapeutics for modulating inflammatory processes. H
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BMS 193885 synthesis Recent evidence indicates that prolonge
2021-11-09
Recent evidence indicates that prolonged vasoconstriction of conductance and resistance arteries involves VSMCs BMS 193885 synthesis polymerization, through activation of small GTPases [4] and a subsequently transition to a more solid rheology [5]. Actin polymerization occurs in two steps, nucleatio
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Although exhibited high inhibitory activity was found to be
2021-11-09
Although exhibited high inhibitory activity, was found to be metabolically unstable due to the hydrolysis of the phosphate group (data not shown), which prompted us to modify the phosphate moiety of . Comparison of the activities between three compounds bearing no or different spacer groups (, , a
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DZNep is a PRC inhibitor that
2021-11-09
DZNep is a PRC2 inhibitor that inhibits S-adenosylhomocysteine hydrolase, resulting in cellular accumulation of S-adenosylhomocysteine. S-adenosylhomocysteine is a competitive inhibitor of methyl donor for methyltransferases [38]. DZNep targets EZH2 by reduction in the level of the enzyme H3K27me3 a
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