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At baseline mutant allele frequency of EGFR in tissue and
2021-03-16
At baseline, mutant allele frequency of EGFR in tissue and plasma samples did not correlated with anti-tumor response (Supplementary Fig. 1). Among 35 patients who were positive for cell-free DNA (cfDNA) at baseline, changes of cfDNA during treatment were analyzed. Negative conversion (NC) of cfDNA
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With respect to the muscle compartment only low protein expr
2021-03-16
With respect to the muscle compartment, only low protein expression of ASB9 has been detected in healthy human skeletal muscle [as reported in the Human Protein Atlas (HPA)], whereas high levels of Asb5 protein expression are detected in mammalian skeletal muscle, which appears to be important in th
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The interface between the E ligase and
2021-03-16
The interface between the E3 ligase and the E2 enzyme can vary, and ZNF451 and SP-RING ligases stabilize this interaction via noncovalent binding to a scaffold SUMO (SUMOB) on the backside of the E2 (Cappadocia et al., 2015; Eisenhardt et al., 2015; Streich & Lima, 2016). By contrast, RanBP2 does no
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BI 2536 br Materials and methods br Results br Discussion Th
2021-03-16
Materials and methods Results Discussion The phosphatidylinositol 3-kinase-like protein kinases, ATM, ATR, and DNA-PK, have all been implicated in H2AX phosphorylation in response to different stimuli [37], [41], [42], [43], [44], [45]. We show here that H2AX is phosphorylated in rodent and
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br As mentioned above defects in the
2021-03-16
As mentioned above, defects in the DNA ligase IIIα-interacting protein TDP1 have been identified as the cause of the hereditary neurodegenerative disease, spinocerebellar ataxia with axonal neuropathy 1 (El-Khamisy et al., 2005). In addition, defects in two other DNA repair proteins, aprataxin and
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Since the initial identification of DNA ligase inhibitors by
2021-03-16
Since the initial identification of DNA ligase inhibitors by a structure-based approach [[18], [26]], there have been several reports describing LigI inhibitors using computer modelling and derivatives of the original DNA ligase inhibitors [[49], [50], [51]]. While these studies have shown that the
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In this study we examined
2021-03-16
In this study, we examined a possible association between the 19-bp Bexarotene australia and the 9-bp repeat in the DHFR gene and the risk of spina bifida in 121 mothers of a spina bifida affected child, 292 control women, 109 spina bifida patients and 234 pediatric controls using a case-control de
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Interaction between neutrophils and ECs
2021-03-16
Interaction between neutrophils and ECs represents the first step of the cellular phase of the inflammatory response, and provide the best condition for the transfer of the PMNL-derived LTA4 to the ECs, leading to the transcellular formation of cysteinyl-LTs. It is intriguing therefore to think that
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Acidic substituents showed moderate biochemical activity but
2021-03-16
Acidic substituents () showed moderate biochemical activity, but these compounds showed reduced cellular potency. Additional compounds bearing a carboxylic ABT737 were also prepared and tested (data not shown). All of acidic compounds showed low cellular potency regardless of their biochemical acti
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Introduction Eicosanoid lipid prostaglandin D PGD is
2021-03-16
Introduction Eicosanoid lipid prostaglandin D2 (PGD2) is the major prostaglandin produced by activated mast daunorubicin (Lewis and Austen, 1981). The physiological function of PGD2 is mainly mediated by two G protein-coupled receptors (GPCRs), PGD2 receptor 1 and 2 (DP1 and DP2), which share mode
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Within the BLA both CRF and the CRF receptor
2021-03-16
Within the BLA, both CRF and the CRF1 receptor have been shown to functionally regulate synaptic activity. In vivo, CRF release into the BLA originates from projections from the CeA (Roozendaal, Brunson, Holloway, McGaugh, & Baram, 2002). Central administration of both CRF and CRF1 agonists has been
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The majority of pro inflammatory cytokines
2021-03-15
The majority of pro-inflammatory cytokines are regulated by NFκB, and recently, it has been found that p38 MAPK partly regulates NFκB-driven gene EZ Cap Reagent AG by increasing the association of the basal transcriptional factor, TATA-binding protein, with the C terminus of p65 subunit of NFκB and
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Protein kinase casein kinase CK
2021-03-15
Protein kinase casein kinase 1 (CK1) comprises a family of highly related, constitutively active serine/threonine protein kinases (reviewed by [15]). CK1 is involved in controlling a wide variety of different cellular events including protein turnover [16], [17], nuclear import [18] and the cellular
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phospholipase inhibitor br Nuclear estrogen receptors Indire
2021-03-15
Nuclear estrogen receptors: Indirect genomic signaling As mentioned earlier, the transcription of several genes that do not contain EREs in their promoter regions can also be regulated by estradiol, without direct binding of the estrogen receptors to the DNA. According to the most recent reports,
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lumiracoxib This study showed that ER redox disturbance asso
2021-03-15
This study showed that ER-redox disturbance-associated ER stress is linked to cytoplasmic chaperone signaling, including HSP90 stability and its client protein, eNOS. The highly increased PERK and IRE-1α lead to dissociation with the chaperone protein, thereby decreasing HSP90 stability (Fig. 5B). S
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