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br Introduction Addiction to opioids such as morphine is
2020-08-06
Introduction Addiction to opioids such as morphine is a chronic disorder that affects the mesocorticolimbic dopaminergic pathway in the brain. Activation of the pathway ultimately leads to dopamine release in the nucleus accumbens (NAc) (Di Chiara et al., 1998) and stimulation of dopamine recepto
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In contrast to two ended exogenously induced
2020-08-06
In contrast to two-ended exogenously induced DSBs, which can be repaired by HR and c-NHEJ, one-ended DSBs arising at the replication fork are predominantly repaired by HR (Moynahan and Jasin, 2010). Such DSBs occur endogenously when replication forks encounter spontaneous kx2 mg damage and/or single
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Based on these results we set out
2020-08-06
Based on these results, we set out to identify and molecularly characterize proteins downstream of DDR1. We performed a modified two-hybrid screen, where the bait and the target library were expressed in bacteria [16]. Fusing the intracellular domain of DDR1 to the bait protein and overexpression in
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It is important to note that some cord blood
2020-08-06
It is important to note that some cord blood samples in vaginal and C-section deliveries show very low cytokine expression. However, more vaginal cord blood samples showed increased Glucose Uptake Fluorometric Assay Kit of IL-6 and IL-8 whereas more C-section cord blood samples show increased TNF-a
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In N crassa a point mutation conferring
2020-08-06
In N. crassa, a point mutation conferring a single amino oicr mutation (His to Arg substitution at amino acid 351 within catalytic domain VII of the kinase) of COT-1 protein resulted in the formation of a temperature sensitive strain, exhibiting severe morphological defects at temperatures higher t
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Using four different Pichia Pink
2020-08-06
Using four different Pichia Pink strains and two different pPink vectors (Table 1), eight different yeast strains were obtained. The level of recombinant proteins produced was compared in the eight strains by P4H radioactive enzymatic assay. The highest enzymatic activity was obtained in the αβH4 st
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br Experimental Procedures br Author Contributions br Acknow
2020-08-06
Experimental Procedures Author Contributions Acknowledgments We thank the Mouse Modeling, Integrated Microscopy, and FACS Facilities of IGB-CNR, Naples. Dr. Laura Pisapia is acknowledged for flow cytometry analyses. We are grateful to Prof. Chris Ponting and George A. Calin for insightful s
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An Ubl modification requires several steps
2020-08-06
An Ubl modification requires several steps that are catalyzed by three enzymes, referred to as E1 (activating enzyme), E2 (conjugation enzyme), and E3 (ligase). The SUMO E1 is a heterodimer of SAE1 and Uba2 (also known as SAE2). In brief, an Ubl is first activated by E1 through ATP hydrolysis and fo
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Even if the angiotensin II perfusion model reproduces the ma
2020-08-05
Even if the angiotensin II perfusion model reproduces the main features of human aneurysm including ECM degradation, leukocyte extravasation, and concomitant presence of atherosclerosis, it is associated with medial dissection and intramural hematoma. In addition, the AAA usually develops in the sup
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Collectively the results presented here provide
2020-08-05
Collectively, the results presented here provide new insights into ligand binding, clustering, spatial distribution, and phosphorylation of DDR1b and DDR2 in response to soluble collagen I. As depicted in the cartoon of Scheme 1, we postulate a model in which the spatial distribution and assembly of
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In astrocytes mitogen activated protein kinases MAPKs are ac
2020-08-05
In astrocytes, mitogen-activated protein kinases (MAPKs) are activated after OGD-induced ischemic injury (Yung and Tolkovsky, 2003, Niu et al., 2009) and they regulate induction of AQP expression (Arima et al., 2003, McCoy and Sontheimer, 2010). It is well known that MAPKs, including extracellular s
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The leukotrienes are a group of
2020-08-05
The leukotrienes are a group of major pro-inflammatory lipid mediators derived from the lipoxygenase pathway of the arachidonic NK 252 metabolism and were so named, because of the salient feature that they can be produced by leukocytes and they have a common conjugated triene in their structure. Th
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Connexins the structural proteins of gap junctions are a
2020-08-05
Connexins, the structural proteins of gap junctions, are a family of transmembrane proteins that oligomerize into hemichannels containing six connexin subunits [9]. Upon reaching the cell surface, two hemichannels pair to complete an intercellular gap junction channel, which directly links the cytop
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Paraffin embedded tissue blocks were transferred from the
2020-08-04
Paraffin embedded tissue blocks were transferred from the University of Florence, Florence, Italy, to the Department of Cellular Pathology at the Royal Free Hospital, London, UK, where the study was performed. Each tissue block was processed according to the reported CPA method and analysed for coll
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br Discussion The use of co
2020-08-04
Discussion The use of co-translational incorporation during fermentation [27] to introduce Hyp residues instead of Pro residues in a bacterial collagen has been demonstrated. Inclusion of NaCl in the medium further increases the level of Hyp incorporation. It has been proposed [27] that this is d
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