• br Discussion In this pilot study we report that sequential

  2019-06-18

  

  Discussion In this pilot study, we report that sequential treatment of low dose clofarabine and lenalidomide is safe and feasible for elderly patients with high risk MDS and AML. Only one subject developed dose limiting toxicity (liver dysfunction) from lenalidomide consolidation therapy. Pre-tre

• It is noteworthy that even with low tumor burden in

  2019-06-17

  

  It is noteworthy that, even with low tumor burden in these patients following CR, peak value at CR status is still a useful indicator for OS, both in the whole cohort, and more importantly, in the intermediate-risk subgroup. Slope is mainly determined by tissue vascularization and perfusion, but cap

• MK 571 Introduction Benign tumours of the bone

  2019-06-17

  

  Introduction Benign tumours of the bone consist of a wide variety of different neoplasms. These tumours vary in terms of incidence, clinical presentation and require a diverse array of therapeutic options. The incidence of benign bone tumours is debated due to their often asymptomatic presentation

• Another key challenge requires special

  2019-06-17

  

  Another key challenge requires special attention in improving maternal health in western China. On the basis of recent estimates, China has more than 250 million so-called rural-to-urban migrants who move from the countryside to cities to seek better paid jobs. A substantial number of these people c

• Early repolarization is often also observed in Brugada syndr

  2019-06-17

  

  Early repolarization is often also observed in Brugada syndrome patients [30–34]. In this study, 34% of Brugada syndrome patients exhibited early repolarization in inferolateral leads. Clinical characteristics, inducibility, and arrhythmic event rate were similar between patients with and without ea

• A year old female patient was referred to us

  2019-06-15

  

  A 55-year-old female patient was referred to us for daunorubicin of an implantable cardioverter-defibrillator (ICD) after cardiac arrest due to idiopathic ventricular fibrillation. As she was young and had no indications for cardiac resynchronization therapy or bradycardia support, she was screened

• Independientemente del estado de nimo de los

  2019-06-15

  

  Independientemente del estado de ánimo de los agentes del gobierno colonial, ante el fin de la ocupación militar, La Lucha presentaba el advenimiento de la República de Cuba como un hecho con claroscuros para diferentes sectores de la sociedad cubana; por un lado, se anhelaba la salida del gobierno

• The reduction in mother to child transmission MTCT

  2019-06-15

  

  The reduction in mother-to-child transmission (MTCT) of HIV is one of the greatest success stories of the antiretroviral therapy (ART) era. However, evidence is accumulating that, despite avoiding HIV, HIV-exposed uninfected (HEU) infants have more infectious morbidity and mortality than HIV-unexpos

• In an effort to determine

  2019-06-15

  

  In an effort to determine whether the primary tumour might be responsible for “fertilising” the bone “soil” ready for the cancer “seed”, we recently found that a hypoxic gene signature, and more specifically the secreted enzyme lysyl oxidase (LOX) was closely associated with bone metastasis, specifi

• br Conclusions br Disclosures br Funding Sources br

  2019-06-15

  

  Conclusions Disclosures Funding Sources Introduction Pulmonary vein isolation (PVI) has become an accepted treatment for atrial fibrillation (AF) [1]. The efficacy of PVI is sometimes insufficient, and atrial substrate modification of target specific AF signals indicating the substrate r

• br Malaria is a major public health problem and a

  2019-06-15

  

  Malaria is a major public health problem and a leading cause of mortality worldwide, especially in sub-Saharan Africa, where 90% of the world\'s 627 000 malaria deaths occur every year. However, the disease is usually curable if diagnosed quickly. Diagnosis is often made on the basis of clinical s

• enzyme substrate Por su parte Juan Carlos Grijalva titula su

  2019-06-15

  

  Por su parte, Juan Carlos Grijalva titula su artículo “A caballo, por la ruta de los libertadores: el legado mesiánico y elitista de José Vasconcelos en Ecuador”. Grijalva explica que el ensayista mexicano llegó enzyme substrate Ecuador el 17 de junio de 1930 procedente de Colombia, cabalgando los A

• onde introduzimos a negritude como uma concep o

  2019-06-15

  

  É onde introduzimos LBH 589 negritude como uma concepção adotada pelos intelectuais e movimentos sociais ligados à causa negra no Brasil. A negritude foi conceituada por seu criador, o poeta e intelectual Aimé Cesairé, como “o simples reconhecimento do fato de ser negro, a aceitação de seu destino,

• A number of studies have shown that

  2019-06-14

  

  A number of studies have shown that zoledronic p38 inhibitor has the ability to potentiate effects of anti-tumor agents such as doxorubicin [21] or everolimus [22]. In a recent paper the combination of chemotherapy with a single infusion of 4mg zoledronic acid in patients with breast cancer was sho

• purchase Volasertib Conflict of interest br Authors contribu

  2019-06-13

  

  Conflict of interest Authors׳ contributions Acknowledgments This work was supported by grants from the Associazione Italiana Lotta alle Leucemie, Linfoma e Mieloma (AIL) – Sezione ‘Luciano Pavarotti’ Modena-ONLUS (to FF and LP) and from the Associazione Italiana per la Ricerca sul Cancro (AIR

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