• Leucovorin Calcium in Tumor–Stroma Translation

  2026-08-22

  Leucovorin Calcium is more than a methotrexate rescue reagent: it is a mechanistic probe for testing how folate availability, tumor context, and stromal composition shape treatment response. This article connects calcium folinate biology with patient-derived gastric cancer assembloids and provides practical guidance for designing more informative translational assays.

• HyperFluor 488 Goat Anti-Rabbit IgG: Practical Guide

  2026-08-21

  HyperFluor™ 488 Goat Anti-Rabbit IgG (H+L) Antibody provides fluorescent detection of rabbit primary antibodies in immunofluorescence, microscopy, immunohistochemistry, immunocytochemistry, and flow-based workflows. It should be used only after confirming rabbit-primary compatibility and should not be treated as validated for non-rabbit primaries or untested applications without additional optimization.

• Bile Acid Subtypes Reveal Immune Dysfunction in CRC

  2026-08-20

  Feng et al. developed a bile acid metabolism-based molecular classification for colon adenocarcinoma and linked the bile-low subtype to shorter survival and altered immune-cell infiltration. The study further identified CLCA1, UGT2A3, and ZG16 as candidate markers for tumor biology, immune dysfunction, and biomarker-focused colorectal cancer research.

• PDHA1 Succinylation and Immune Escape in Cholangiocarcinoma

  2026-08-20

  The reference study defines a metabolic–immune pathway in which PDHA1 K83 succinylation increases PDH activity, promotes α-ketoglutarate accumulation, and suppresses macrophage MHC-II antigen presentation through OXGR1–MAPK signaling. Its findings connect tumor metabolic flux with chemotherapy resistance and suggest that inhibiting succinylation may improve gemcitabine–cisplatin responses, although clinical validation remains necessary.

• Sulforaphane, Oxidative Stress, and NLRP3 in Colitis

  2026-08-19

  A 2024 mouse study links sulforaphane-mediated reduction of reactive oxygen species with suppression of NLRP3 inflammasome signaling in dextran sodium sulfate-induced colitis. Its combined in vivo and macrophage-cell experiments provide a mechanistic framework for studying redox-sensitive intestinal inflammation while highlighting the limits of translating preclinical dosing to human disease.

• Alda 1 and ALDH2: From Aldehyde Detoxification to Repair

  2026-08-19

  Alda 1 is an ALDH2 activator that connects mitochondrial aldehyde detoxification with emerging strategies for cardioprotection, cardiac repair, and radiation-induced dermatitis mitigation. This thought-leadership article interprets recent evidence showing that ALDH2 activation can promote cardiomyocyte proliferation and delay pressure overload-induced heart failure, while outlining practical study-design principles, translational opportunities, and the limitations researchers should address before moving toward clinical development.

• Solanesol (B8776): Handling and QC Guide

  2026-08-18

  Solanesol (SKU B8776) provides a defined polyisoprenoid alcohol for workflows that require controlled handling of a hydrophobic research compound. It is suitable for selected biochemical and membrane-related studies when prepared in DMSO, but it should not be used in water- or ethanol-based preparations or in diagnostic and clinical workflows.

• Mcl-1 Super-Enhancer Targeting in Glioblastoma

  2026-08-18

  The reference study identifies a super-enhancer around Mcl-1 in glioblastoma and shows that its epigenetic disruption creates synthetic lethality with BCL-2/BCL-XL inhibition. The findings provide a mechanistic framework for apoptosis induction via BCL-XL inhibition while highlighting the model dependence and translational challenges of this combination strategy.

• 4-Ethylphenyl Sulfate at the Gut–Kidney Interface

  2026-08-17

  4-Ethylphenyl sulfate offers a translational bridge between microbiota-derived chemistry, neurobehavioral phenotypes, renal dysfunction, and emerging toxin-removal technologies. This article outlines how to use the metabolite as a controlled research probe rather than treating it as a standalone biomarker or product-page specification.

• ARCA EGFP mRNA for LNP Assay Design

  2026-08-17

  ARCA EGFP mRNA can function as more than a routine transfection control: it is a calibrated reporter for separating delivery, intracellular release, and mammalian cell gene expression. This article connects the R1001 reporter to lipid nanoparticle development and explains how to interpret fluorescence without overstating transfection performance.

• AG-490 Workflow for JAK2/STAT6 Studies

  2026-08-16

  AG-490 (Tyrphostin B42) helps researchers test whether JAK2-linked signaling contributes to exosome-driven macrophage polarization, while its EGFR and ErbB2 activity creates important pathway-specific controls. This practical guide covers treatment design, phospho-signaling readouts, IL-2 applications, solubility management, and troubleshooting for cancer research.

• MLKL–Lysosome Crosstalk in Necroptosis

  2026-08-15

  The reference study identifies lysosomal membrane permeabilization as a direct consequence of MLKL polymerization and places cathepsin B release between necrosome activation and plasma membrane rupture. Its imaging, perturbation, and engineered MLKL-domain experiments provide a mechanistic framework for studying lysosomal protease contributions to necroptosis.

• BGJ398: A Precision Framework for FGFR Research

  2026-08-14

  BGJ398 (NVP-BGJ398) is a selective FGFR1/2/3 inhibitor for dissecting receptor-driven biology. This article connects its oncology applications with a 2025 comparative developmental study to show how model choice, spatial assays, and perturbation timing improve FGFR research.

• Dibutyryl-cAMP: Astrocyte Reprogramming Workflows

  2026-08-14

  Dibutyryl-cAMP, sodium salt provides a practical way to perturb intracellular cAMP during astrocyte-to-neuron reprogramming, while preserving clear separation between signaling effects and transcription-factor-driven fate conversion. This guide covers dosing design, PKA-centered readouts, functional validation, and troubleshooting for neural and inflammatory cell models.

• Moesin as a Biomarker of Endothelial Injury in Sepsis

  2026-08-13

  The reference study identifies circulating moesin (MSN) as a candidate biomarker of endothelial injury and sepsis severity, linking serum MSN with SOFA scores, procalcitonin, and experimental lung damage. Its combination of patient data, mouse models, and endothelial-cell experiments also suggests that MSN contributes mechanistically through ROCK1/MLC and NF-κB signaling.

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