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In this study we showed that TRIM promotes ASK
2024-03-29
In this study, we showed that TRIM48 promotes ASK1 activation through ubiquitination-dependent degradation of a negative regulator of ASK1 activation, protein arginine methyltransferase 1 (PRMT1). Knocking down TRIM48 suppressed oxidative-stress-induced cell death mediated by ASK1, and the additiona
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Currently NSAIDs which achieve antineoplastic actions mainly
2024-03-29
Currently, NSAIDs which achieve antineoplastic actions mainly through apoptosis are emerging choice in chemotherapy. Their antineoplastic effects were demonstrated before in tumor-bearing models [5], [6], [7]. Through in vitro cell models, we identified an indomethacin-activation of ceramide/PP2A/Ak
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Sodium 4-Aminosalicylate australia br Materials and methods
2024-03-29
Materials and methods Results Discussion Endophilin A1 is a membrane-binding protein that is mainly distributed in the central nervous system (Giachino et al., 1997), localizes in the dendritic shafts and spines of mature neurons (Yang et al., 2015), and relates to the function and morpholo
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Fidaxomicin br Concluding Remarks and Future Perspectives br
2024-03-29
Concluding Remarks and Future Perspectives Disclaimer Statement Introduction Aldehyde dehydrogenase ALDHs (E.C. 1.2.1.3) are multigene family of NAD(P)+-dependents group of structurally and functionally related ubiquitously distributed enzymes involved in the specific and irreversible oxida
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NAD+ Polycyclic aromatic hydrocarbons PAHs are
2024-03-29
Polycyclic aromatic hydrocarbons (PAHs) are abundant environmental contaminants that are produced by the incomplete combustion of organic matter, combustion engines, residential heating, NAD+ burning, and industrial activities (Gelboin, 1980; Phillips, 1999, Phillips, 2002). Some PAHs have been rec
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Given the profound expression of HT A
2024-03-28
Given the profound btk inhibitor of 5-HT1A and 5-HT2A in the hippocampal CA1 region, and their potential to complex with mGluRs, the objective of this study was to examine if sleep deprivation alters the expression of 5-HT1A and 5-HT2A receptors and determine whether potential changes are reversible
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br Funding br Introduction The interest in the
2024-03-28
Funding Introduction The interest in the effects of endocrine disrupting chemicals (EDCs) in the aquatic environment continues to increase over the past decade, specifically those that act on steroidogenic pathways. EDCs that include synthetic androgenic and estrogenic compounds can severely a
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These results must also be addressed in light
2024-03-28
These results must also be addressed in light of porcine AMPKγ3R200Q (RN−) mutation. Pigs harboring this mutation produce meat with an abnormally low ultimate pH (pHEG00229 meat (Copenhafer et al., 2006, Lundström et al., 1998, Milan et al., 2000). This extremely low pH is very close to the isoelect
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br Experimental br Results and discussion br Conclusion
2024-03-28
Experimental Results and discussion Conclusion Acknowledgments This work is supported by the National Basic Research Program of China (973 Program 2016YFA0201201 and 2013CB932702), a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (PAP
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Telomerase action at the telomere is highly
2024-03-28
Telomerase action at the telomere is highly regulated; it preferentially elongates the shortest telomeres, and recruitment of the enzyme complex to the telomere occurs in mid-S phase of the cell cycle (Bianchi and Shore, 2007, Britt-Compton et al., 2009, Teixeira et al., 2004, Hemann et al., 2001, T
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br Acknowledgements M M M is
2024-03-28
Acknowledgements M.M.M. is the William Dow Lovett Professor of Neurology and is supported by grants from the Michael J. Fox Foundation for Parkinson's Research, the American Parkinson Disease Association, the New Jersey Health Foundation/Nicholson Foundation, and by the National Institutes of Hea
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AP was originally described as a
2024-03-28
AP-1 was originally described as a heterodimer of the bZIP proteins c-Jun and c-Fos. The experiments described here showed that stimulation of TRPV1 channels induced the expression of both of these classical constituents of AP-1. The essential role of both proteins was analyzed in a series of experi
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CGRP 8-37 (rat) synthesis br Experimental and computation St
2024-03-28
Experimental and computation Standard samples of artemisinin (1) and artemether (2) were purchased from China National Institutes for Food and Drug Control. Their ECD spectra, at a concentration of 1.0–5.0mg/mL in ethanol, were recorded in a quartz cuvette of 1mm optical path length using a Jasco
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difluprednate Vascular interventional radiology VIR laborato
2024-03-28
Vascular interventional radiology (VIR) laboratories perform a myriad of procedures ranging from simple tunneled peripherally inserted central catheter lines to complex transjugular intrahepatic portosystemic shunt placements. Infections are a common complication in the VIR environment; thus, the pr
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Angiogenesis is a process of formation of new vessels
2024-03-28
Angiogenesis is a process of formation of new vessels from arterial vascularization created by endothelial cells. It is essential for the continuous growth of the tumor because it supplies the tumor with nutrients and oxygen, and eliminates cellular waste, which can be toxic to cancer cells [8]. Inf