Archives
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G quadruplex structures can be resolved
2022-08-16
G-quadruplex structures can be resolved by helicases. Consistently, many helicases are aberrantly expressed in cancer TNP-470 [47]. In this study, we correlated HOXC10 expression with that of all helicases using a microarray dataset derived from 759 breast cancer patients [36] and discovered that C
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Histamine Phosphate In principle an ideal Fenton reaction el
2022-08-16
In principle, an ideal Fenton reaction element should have multiple oxidation states to form a redox cycle in the process of H2O2 decomposition to HO•. Although iron is very effective in catalyzing Fenton reaction, it requires a low pH value (pH 2-4) to reach the optimal catalytic efficiency, which
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Aberrant activity of PRC as a
2022-08-16
Aberrant activity of PRC2 as a result of over expressed EZH2, has been frequently seen in a wide range of human cancers including breast and prostate tumors [10]. However, leukemia-associated epigenetic aberrations are not fully understood [7]. Herein, we will overview the current knowledge of epige
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Aberrant expression of HKII may
2022-08-16
Aberrant expression of HKII may be a required feature for cancer development and progression. Overexpression of HKII has been reported in tumor tissues of cancer patients with liver [9], ovary [8], [24] and larynx [25]. The clinical significance of HKII in cancer was noted as overexpression of HKII
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Introduction Epigenetic alterations play an important role i
2022-08-15
Introduction Epigenetic alterations play an important role in carcinogenesis. Aberrant promoter CpG island hypermethylation causes transcriptional gene silencing [1], and has been documented for a number of genes in prostate cancer (PCA) [2]. Histone modifications are also important regulators of t
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All HFD fed groups in
2022-08-15
All HFD fed groups in our study, having significantly higher levels of EE (heat production) is consistent with previous studies [91], where a significant increase in EE was observed within just one week of HFD feeding [81]. It is hypothesized that this phenomenon is due to the increased body mass an
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Autophagy as an important cellular process has drawn attenti
2022-08-15
Autophagy as an important cellular process has drawn attentions to its role in cardiovascular systems [16]. Autophagy is a self-digestion and degradation process that recycles the contents of the cytosol, including macromolecules and cellular organelles, resulting in self-repair and conservation for
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br Discussion Naloxone and CTAP
2022-08-15
Discussion Naloxone and CTAP were able to alter the febrile response induced by gp120. This effect was particularly evident during the initial hours following gp120 administration (90–210min). We also investigated the potential role of the delta-2 opioid receptor in gp120-induced fever. The delta
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Overall our results indicated the involvement of
2022-08-15
Overall, our results indicated the involvement of GABAAR in controlling GnRH/LH release through mechanism which included GABA action on molecular processes leading to GnRH biosynthesis. This is consistent with previous in vivo [14,54] and in vitro [55] studies in ewes suggesting that GABA inhibits G
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How do myofibroblast sources compare between bone marrow
2022-08-13
How do myofibroblast sources compare between bone marrow and other organs? Perivascular 7-Nitroindazole with MSC properties significantly contribute to fibrosis in muscle, fat, skin, heart, kidney, lung, and liver (reviewed in Iwayama et al., 2015) and activate Gli1 in many of these organs (Kramann
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In addition to inactivation of Notch we found
2022-08-13
In addition to inactivation of Notch, we found that the combination of BTZ and GSI-I downregulated ERK phosphorylation in ALK+ ALCL cells, and we speculate this may occur through the inhibition of upstream regulators of the ERK pathway. These findings emphasize the functional complementation of the
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Notch signaling maintains the balance between neural
2022-08-13
Notch signaling maintains the balance between neural stem cells and neural progenitors (Aguirre et al., 2010, Basak and Taylor, 2007, Mizutani et al., 2007). Conditional knock out of Notch causes depletion in the progenitor pool, showing that Notch is required for the maintenance of neural stem cell
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The C terminal regions in both
2022-08-13
The C-terminal regions in both FGF19 and FGF21 define their KLB interaction [15], [16], [23], [25]. However, less than 40% identity in comparative alignment of C-terminal sequences for these two proteins (Table 1) suggests that their interaction with KLB may require higher-order association with oth
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br Conclusion In summary a series of
2022-08-13
Conclusion In summary, a series of novel GPR40 agonists bearing phenylpropiolic acetylcholine chloride australia motif with favorable metabolic stability were prepared and evaluated for their activities as GPR40 agonists. Among them, compound 9 was identified as a structurally distinct GPR40 ago
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Recently considerable effort has been invested in developing
2022-08-13
Recently, considerable effort has been invested in developing FDPS inhibitors based on alternative scaffolds (including nonbisphosphonates) that allow other tissue types and parasite-derived forms of FDPS , to be targeted. There are several limits in analyzing inhibitors of FDPS activity: the most