Archives
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Glucocorticoid is a major regulator of
2021-11-30
Glucocorticoid is a major regulator of body's response to stress (Armario, 2006). Repeated injections of the glucocorticoid corticosterone (CORT) in mice have been shown to produce an animal model of depression (Zhao et al., 2008). Further study of this phenomenon suggested that prolonged CORT expos
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Natural product based drug discovery
2021-11-30
Natural-product-based drug discovery can be enhanced with computational methods [205]. Because most of the reported small-molecule natural inhibitors of fMLF-induced functional responses were not evaluated in Z-Ligustilide binding assays, we used molecular modeling to predict how well these compoun
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Immunohistochemistry using anti FFAR antibodies
2021-11-30
Immunohistochemistry using anti-FFAR1 antibodies revealed immunoreactivity for FFAR1 in association with the cell membrane of the hepatocytes (Figure 2). However, the anti-FFAR2 antibody was not suitable for immunohistochemistry under the tested conditions (data not shown). Fatty liver is an import
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By measuring the accumulation of
2021-11-30
By measuring the accumulation of unprenylated Rap1a as a surrogate marker for the inhibition of FPPS [8], [9], [10], [11], we found that upregulation of FPPS expression in Hela cells reduced the accumulation of unprenylated Rap1a in response to 24h' treatment with 0–50μM ZOL. As expected, cells cult
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br Nanoscale Cortical Actin Remodeling in Regulated Exocytos
2021-11-30
Nanoscale Cortical Actin Remodeling in Regulated Exocytosis The network of cortical plerixafor is formed by numerous fine actin filaments, which are only about 10nm in diameter [52]. Although the microscale role of the cortical actin network in vesicle exocytosis is well established, the function
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UK 356618 br Dynamic Localization of Hippo Pathway Component
2021-11-30
Dynamic Localization of Hippo Pathway Components The observation that Wts normally localizes with an inhibitor, Jub, raised the question of how and where Wts normally becomes activated. Under conditions of pathway activation in Drosophila imaginal discs, Wts relocalized from Jub to Ex, where it i
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br References and recommended reading Papers of particular
2021-11-30
References and recommended reading Papers of particular interest, published within the period of review, have been highlighted as: Introduction Male sexual maturation includes gonadal maturation, secondary sexual characteristics, and the attainment of reproductive capacity [1]. Male sexual di
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Some data also suggested that CCR could influence the
2021-11-30
Some data also suggested that CCR5Δ32 could influence the progression of HCV-related liver diseases (Goulding et al., 2005; Hellier et al., 2003; Wald et al., 2004). However, after stratifying HCV+ individuals according to clinical/histological criteria, no association of CCR5Δ32 with these HCV-rela
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Despite efforts over the past decade to
2021-11-30
Despite efforts over the past decade to shed light on the endosomal maturation process and its underlying Rab conversion, the context in which all the involved protein components interact needs to be further elucidated. After defining single components and modules of the machinery important for endo
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Despite the association with asthma
2021-11-30
Despite the association with asthma, it is not surprising that we did not find a relation between the percent predicted FEV1 and SNPs in GSNOR. FEV1 measured on a routine clinic visit is likely to be normal in most asthmatic children. FEV1 in children reflects a complex mix of factors in the growth
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PI3K Akt mTOR Compound Library receptor br Introduction Athe
2021-11-30
Introduction Atherosclerosis is a chronic inflammatory disease characterized by lipid and leukocyte accumulation within the arterial wall. Homocysteine (Hcy) is a thiol-containing amino PI3K Akt mTOR Compound Library receptor derivative derived from the metabolism of dietary methionine. Epidemiol
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br Conclusions br Acknowledgement br Introduction
2021-11-30
Conclusions Acknowledgement Introduction The macrophage is an important cell species that plays key roles in innate immune responses and inflammatory reactions through phagocytosis of foreign bodies and secretion of inflammatory mediators such as interleukin (IL)-1, tumor necrosis factor (T
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Type diabetes mellitus T DM causes vascular complications
2021-11-30
Type 2 Alisol B 23-acetate (T2DM) causes vascular complications and is a major public health problem associated with lifestyle diseases such as obesity, liver steatosis, hypertension, and so on. Although serum lactate is reportedly elevated in diabetic patients [12], [13], the physiological effects
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br Manganese based imaging probes br Imaging of
2021-11-30
Manganese-based imaging probes Imaging of vesicular monoamine transporter 2 (VMAT2) Imaging of sulfonylurea receptor 1 (SUR1) In mammals, insulin secretion is mediated by the membrane potential of pancreatic β-cells. Increases in glucose levels lead to blocking of ATP-sensitive potassium ch
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In breeding season small mammals increase dispersal and soci
2021-11-29
In breeding season, small mammals increase dispersal and social communication to maximize their opportunity to mate. In the present study, we found that gerbils in April showed more locomotion and exploratory behavior in the open field test. Moreover, subadult gerbils in April and July were more lik