Archives
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br Acknowledgements br Introduction Laryngeal cancers are th
2021-05-14
Acknowledgements Introduction Laryngeal cancers are the most frequent cancers of the head and neck region and their occurrence is strongly associated with the exposure to cigarette smoke and the consumption of strong alcohols. Almost all laryngeal cancers are squamous cell carcinomas. Usually
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br Materials and methods br
2021-05-14
Materials and methods Results and discussion In the present work, we have applied two methodologies, CoMFA and CoMSIA to build 3D-QSAR models. There is no crystal structure available; therefore, an indirect method i.e., a ligand-based approach is the method of choice. The highly active molecul
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One common method to replace the wet limestone
2021-05-14
One common method to replace the wet limestone process is the use of an amine-based solution as an absorbent to capture SO2. However, almost all of the common amine-based absorbents are highly volatile compounds, whose emissions are air pollutants themselves. Therefore, it is desirable to either use
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Another interesting study was that by Kotyuk et al
2021-05-14
Another interesting study was that by Kotyuk et al. (2015), who investigated the association between COMT rs4680 and personality in elderly people. The authors analysed the association between COMT rs4680 and NEO-FFI. The GG porcine correlated with lower mean Neuroticism score and higher Agreeablene
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Inopportunely normal aging brings about decreases in frontal
2021-05-14
Inopportunely, normal aging brings about decreases in frontal D1 receptor densities and a gradual decline in postsynaptic markers of dopamine in striatal, neocortical, and limbic areas of the salvinorin a mg (Bäckman et al., 2006, de Keyser et al., 1990, Karrer et al., 2017, Suhara et al., 1991, Wa
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LDE225 Diphosphate LP a levels are lowered by
2021-05-14
LP(a) levels are lowered by combined oral hormone therapy [80], [81], [82], [83], [84], whereas for most studies using transdermal HRT little or no changes have been observed [85], [86], [87]. Oral versus transdermal administration In general most markers are influenced in a similar way by oral
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br The modulation of ER from SERMs to TSECs Continued
2021-05-14
The modulation of ERα: from SERMs to TSECs Continued efforts to provide women with efficacious menopausal therapies have generated interest in the development of selective ml7 receptor modulators (SERMs). Similar to estrogens, SERMs have been shown to bind to ERs with high affinity, despite lack
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PF 04418948 We recently employed a functional drug screening
2021-05-14
We recently employed a functional drug screening approach to identify mithramycin as an inhibitor of EWS–FLI1. In our study, we employed a stepwise approach involving a luciferase primary screen and a novel multiplex PCR screen to evaluate over 50,000 compounds to identify mithramycin as an inhibito
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More than thirty enzymes with
2021-05-14
More than thirty enzymes with PLA2 activity have been described and, based on sequence similarities, they are currently classified in 16 groups, each containing several sub-groups [16]. However, based on biochemical features these enzymes are frequently grouped into six major families: secreted phos
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Glycolysis is important to maintain the vital functions
2021-05-14
Glycolysis is important to maintain the vital functions of T. gondi. Extracellular T. gondii shift its Volasertib metabolism towards glycolysis, based on the observation that a relocation of glycolytic enzymes from the cytosol to the pellicle occurs at the time when tachyzoites egress from host cel
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Previous studies have indicated that hSSB may
2021-05-13
Previous studies have indicated that hSSB1 may be phosphorylated at threonine residue 117 (T117) [13] and acetylated at lysine residue 94 (K94) [15], both of which promote hSSB1 function in response to ionising radiation exposure. Mass spectrometry screens of proteins immunoprecipitated with phospho
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br UVC induced DNA damage a model to
2021-05-13
UVC-induced DNA damage: a model to study DNA damage tolerance The UV components of sunlight that reaches the Earth surface are one of the most carcinogenic agents humans are exposed to, and the leading cause of skin cancer [4,12]. UV light causes different types of DNA damage through indirect and
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The larger eukaryotic ligases such as LigI
2021-05-13
The larger eukaryotic ligases, such as LigI and LigIV, also possess an additional N-terminal DNA-binding domain (DBD) that is required for efficient ligation (Fig. 1c) and enables these ligases to encircle DNA [17]. An equivalent helix–hairpin–helix domain is also present in the bacterial NAD-depend
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These data raised from human tissues suggested a
2021-05-13
These data raised from human tissues suggested a potential link between TGF-β1 signaling and linear invadosome machinery that may explain TGF-β involvement in HCC progression and invasion. Using HCC cultured cells, we confirmed that TGF-β1 stimulation increases the production and secretion of collag
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Some mechanistic experiments performed in the early s
2021-05-13
Some mechanistic experiments performed in the early 2000s by Ongusaha et al. [78], suggest that DDR1 induction protects trifluoperazine hydrochloride from apoptosis in a p53-dependent manner, and that impairment of DDR1 expression or function leads to a pronounced increase of DNA damage-induced apop