Archives
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Structural characterization of A S Given the
2020-08-08
Structural characterization of A1S_0222. Given the low specific activity of our protein preparations and the considerable problems to concentrate the protein to levels above 2.5 mg/mL, we employed SAXS to structurally characterize and generate a low-resolution model of A1S_0222 in solution. Fig. 5 a
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Recent studies have shown arsenic could cause autophagic cel
2020-08-08
Recent studies have shown arsenic could cause autophagic cell death in malignant cells, including leukemia and malignant glioma caspofungin [16], [17]. However, at present, little is known about the consequences of arsenic-treated urothelial cells in autophagy and expression of its related proteins
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Taking all the data together we propose
2020-08-08
Taking all the data together, we propose the possible mechanism of glyphosate-induce cell proliferation via estrogen receptor signaling (Fig. 10). Glyphosate may bind to ERα followed by an activation step that starts with the phosphorylation of ERα and activation of other signaling proteins by phosp
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It remains unclear how LINE RNA Nucleolin Kap are
2020-08-08
It remains unclear how LINE1 RNA-Nucleolin-Kap1 are targeted to the Dux cluster. LINE1-Nucleolin-Kap1 may have other interacting partners with DNA binding specificity. For example, YY1 has been implicated in targeting a repressive complex containing Nucleolin to the human DUX4 cluster (Gabellini et
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br Discussion br Conflicts of interest br Acknowledgment
2020-08-08
Discussion Conflicts of interest Acknowledgment Introduction To maximize the benefits and minimize the toxicity of an oncotherapy, targeted therapy has emerged as one of the major modalities for cancer control, with impressive results obtained for a number of cancers. These targets are e
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Previous studies have induced EphB
2020-08-08
Previous studies have induced EphB4 signaling by artificially preclustering ephrin-B2 in solution to generate multimeric receptor-ligand complexes (22, 23). However, these methods do not recapitulate the physical interactions between membrane-bound receptors and ligands. We therefore turned to suppo
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Increased DNA damage due to
2020-08-07
Increased DNA damage due to enhanced oxidative stress has been reported in patients with COPD. Ceylan et al. and Maluf et al. reported that DNA damage is increased in the PBMCs from patients with COPD as compared to healthy individuals [69], [70]. Similar results were found in a study involving lung
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Previous studies have established an essential function for
2020-08-07
Previous studies have established an essential function for GPR183 and its ligand 7α,25-OHC in lymphoid organs and humoral immunity (Gatto et al., 2009, Gatto et al., 2013, Hannedouche et al., 2011, Li et al., 2016, Liu et al., 2011, Pereira et al., 2009, Yi and Cyster, 2013, Yi et al., 2012). We ha
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2602 br Results br Discussion Taking advantage of
2020-08-07
Results Discussion Taking advantage of the highly specific protein–protein interactions among cognate 2602 that mediate SUMO conjugation to substrates, we have developed a novel strategy for achieving inhibition of SUMO conjugation in vivo based on disruption of SUMO E1–E2 interactions. We hav
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br Introduction Malaria remains a
2020-08-07
Introduction Malaria remains a serious parasitic disease in tropical areas due to its high morbidity and mortality rates. It is estimated that 212 million cases occurred globally in 2015, leading to 429, 000 deaths, most of which were in children aged under 5 years in Africa [1,2]. The protozoans
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WM-2474 Aspergillus nigerA niger is another filamentous fung
2020-08-07
Aspergillus nigerA. niger is another filamentous fungus, in which alternative dehydrogenases have been described. Filamentous fungi are a very important group of microorganisms that are used in industry (O’Donnell et al. 2011). Biotechnological production processes using these organisms are often hi
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Piceatannol a polyphenol compound derived from grapes
2020-08-06
Piceatannol, a polyphenol compound derived from grapes and wine shows great antioxidant activity to scavenge free radicals [3]. Lots of researches focus on the effects of piceatannol on cancer cells, like A549, a non-small cell lung cancer line shows piceatannol increases cell apoptosis by enhancing
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br Introduction Addiction to opioids such as morphine is
2020-08-06
Introduction Addiction to opioids such as morphine is a chronic disorder that affects the mesocorticolimbic dopaminergic pathway in the brain. Activation of the pathway ultimately leads to dopamine release in the nucleus accumbens (NAc) (Di Chiara et al., 1998) and stimulation of dopamine recepto
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In contrast to two ended exogenously induced
2020-08-06
In contrast to two-ended exogenously induced DSBs, which can be repaired by HR and c-NHEJ, one-ended DSBs arising at the replication fork are predominantly repaired by HR (Moynahan and Jasin, 2010). Such DSBs occur endogenously when replication forks encounter spontaneous kx2 mg damage and/or single
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Based on these results we set out
2020-08-06
Based on these results, we set out to identify and molecularly characterize proteins downstream of DDR1. We performed a modified two-hybrid screen, where the bait and the target library were expressed in bacteria [16]. Fusing the intracellular domain of DDR1 to the bait protein and overexpression in