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In the present study the expression of the
2020-09-09
In the present study, the (S)-Crizotinib receptor of the CYP2C11 gene and the levels of its protein and activity were decreased in rats with liver insufficiency and in rats after induced dysfunction of the serotonergic system during normal liver function. Moreover, serotonergic system dysfunction d
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Methylated CpGs can recruit transcriptional co repressors to
2020-09-09
Methylated CpGs can recruit transcriptional co-repressors to prevent transcription factors (TFs) from promoting gene expression by tightly packing OSMI-1 structures [38]. Two CpG islands in the IPT5b promoter region showed higher methylation level in M9 rootstock compared to Mr (Fig. 3b). However,
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br Conclusion br Conflicts of interest br Acknowledgements T
2020-09-08
Conclusion Conflicts of interest Acknowledgements This study was financially supported by The Science and Engineering Research Board (SERB), Department of Science & Technology (DST), Government of India under the Fast Track Scheme for Young Scientist to Dr. V. Dhananjayan (No: SB/FT/LS-140/
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Western blotting and flow cytometry was employed
2020-09-08
Western blotting and flow cytometry was employed to assess the DNA-PK inhibition of LTU28 and LTU31 in combination with radiation. It has been previously reported that phosphorylation of DNA-PKcs at the Thr2609 cluster plays an important role in DSB repair and resistance to radiation (Ding et al., 2
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Inhibition of DHODH is reflected by
2020-09-08
Inhibition of DHODH is reflected by an antiproliferative effect on peripheral blood mononuclear EGTA (PBMCs), which can be measured by the inhibitory effect on their phytohemagglutinin (PHA) stimulated growth. The test was performed as described in the reference. Data for few selected compounds are
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DMPO Dehydrogenation by a KSTD is also a crucial step during
2020-09-08
— 1(2)-Dehydrogenation by a Δ1-KSTD is also a crucial step during DMPO degradation of the steroid core. Several Δ1-KSTDs were shown to be active under either aerobic or anaerobic conditions [27,29,47,50,66]. Furthermore, the last common intermediate of both aerobic and anaerobic steroid degradatio
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RNA seq results also support the similarity between ESC
2020-09-08
RNA-seq results also support the similarity between ESC- and YS-derived B-1 progenitors. Bmi1 expression, known as an important gene for self-renewal ability in stem cells, was reduced in ESC-derived B cells compared with YS-derived B cells, and Bmi1 overexpression improved the engraftment of ESC-de
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br Introduction Receptor tyrosine kinases RTKs are
2020-09-08
Introduction Receptor tyrosine kinases (RTKs) are critically involved in the development and progression of human cancers and are therefore useful targets for anti-cancer therapies [1]. The Eph receptors represent the largest subfamily of receptor protein kinases and interact with ligands called
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An intriguing feature of the pre and postsynaptic
2020-09-07
An intriguing feature of the pre and postsynaptic processes at the level of the VTA that have been shown to be mediated by CRF2 receptors [9], [34] is that they are exerted only by agonists with high affinity for both CRF2 receptors and CRF-BP. The four endogenous peptides of the CRF system have hig
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br Materials and methods br Results br Discussion In the
2020-09-07
Materials and methods Results Discussion In the past decade, GWAS have attempted to identify genetic variants that confer risk for many human diseases, whose inherited components remain unexplained (Manolio et al., 2009). In a few cases risk variants identified by GWAS have paved the way fo
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Present study observed failure of PPE usage by
2020-09-07
Present study observed failure of PPE usage by the majority of workers, which may be notable problem and may create a significant health effects due to pesticide exposure. Non-usage of PPE and its ill effects have been reported among farmers in Brazil [24,25] and Nepal [26]. It was reported that use
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br Results and discussion The results and
2020-09-07
Results and discussion The results and subgroup analysis of cholesterol and NCS from the both surveys are listed in Table 2 and shown in Fig. 1, A1 to E2. Common discussion Unlikely to the other NCS assays, a target value for cholesterol could be reported in the present survey. For NCS assays
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In modern science and technology many optimization problems
2020-09-07
In modern science and technology, many optimization problems need to be solved in real time, while these classical methods cannot render real-time solutions to these optimization problems, especially large-scale problems. As a new metaheuristic, particle swarm optimization (PSO) [18], [19] has prove
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br Results br Discussion The advent of TKI treatment
2020-09-07
Results Discussion The advent of TKI treatment has greatly improved CML therapy. Because CML LSCs are less sensitive to TKIs, CML is usually controlled rather than cured, highlighting an unmet clinical need. Developed from our previous finding that CML LSCs are more dependent on Tcf1 and Lef1
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The in vitro cytotoxicity of the prodrugs was assessed
2020-09-05
The in vitro cytotoxicity of the prodrugs was assessed in the LS174T human colon cell line (). The results were found to reflect the stability of the prodrugs, with the unstable urea compounds ( and ) giving relatively poor cytotoxicity differentials between prodrugs and parents (i.e., approximatel
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